| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
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| Autores: |
Coura,Renata dos Santos
Marques,Christiane de Fátima Silva
Koifman,Rosalina J.
Koifman,Sergio
Cabello,Pedro Hernan
Hatagima,Ana
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| Data: |
2007-01-01
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| Ano: |
2007
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| Palavras-chave: |
Cytochromes P450
CYP1A1
CYP2E1
Brazil
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| Resumo: |
The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572007000100001
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.30 n.1 2007
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| Direitos: |
info:eu-repo/semantics/openAccess
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